The death of Friends star Matthew Perry is under investigation following the discovery of prescription drug ketamine in his system, according to reports. Perry passed away in October, and the Los Angeles Police Department (LAPD) is currently seeking to determine the source of the ketamine.
The Los Angeles County Medical Examiner revealed that while traces of ketamine were found in Perry’s stomach, the concentration in his bloodstream was sufficient for general anesthesia. This has prompted a collaborative investigation involving the LAPD, the Drug Enforcement Administration (DEA), and the United States Postal Service.

The investigation was initially reported by TMZ. In December, TMZ obtained a toxicology report from the Los Angeles County Medical Examiner’s Office indicating that Perry died from “the acute effects of ketamine,” leading to cardiovascular overstimulation and respiratory depression.
Ketamine is known to be used for various purposes, including treatment for depression, pain management, and recreational use. The Medical Examiner noted that Perry had been receiving ketamine-infusion therapy, with his last treatment occurring a week and a half before his death. However, the Medical Examiner clarified that Perry’s death could not be attributed to this therapy, as ketamine’s half-life is only three to four hours.

Additional factors contributing to Perry’s death in his jacuzzi were identified as drowning, coronary artery disease, and the effects of buprenorphine. Interviews conducted during the investigation suggest that Perry had been clean for nearly two years, with no alcohol or illicit drugs such as methamphetamine, cocaine, heroin, PCP, or fentanyl found in his system or home.
It was also noted that Perry smoked two packs of cigarettes daily and suffered from chronic obstructive pulmonary disease (COPD)/emphysema and diabetes. The investigation continues as authorities work to uncover more details surrounding his untimely death.